What It Means:

Knox was held out of practice this week and he will miss at least one game. Jamison Crowder (ankle) and Jake Kumerow (ankle) is also out, while Isaiah McKenzie (concussion) is questionable, so look for Khalil Shakir to take on a larger role. Quintin Morris and Tommy Sweeney will likely absorb most of Knox's tight end snaps, but neither offer much fantasy appeal.

The Steelers have the No. 14 overall defense in numberFire's adjusted team rankings, with the No. 11 pass defense and No. 19 run defense. Knox is registering a 10.6% target share and 74.3% offensive snap share through four games.