Fantasy Football: 6 Historical Vegas Trends You Should Know for Week 1

Start Brandin Cooks as a Favorite

To go along with Drew Brees' dominance as a favorite, his receivers also tend to do well in the split.

Brandin Cooks is the most likely receiver to do well based on his historical splits. He has averaged 17.43 fantasy points per game when the Saints are favored and only 9.73 when they're underdogs. Cooks also averages about five points more at home than on the road.

The Saints were favored in six games last season, and in those games, they averaged a shade over three passing touchdowns per game. The number of passing yards also averaged about 377 yards in those contests, giving Cooks plenty of opportunity. They even averaged about four more offensive plays per game as an offense when favored.

The Saints are home favorites, and Cooks is priced at $7,600, the 12th-most expensive receiver on FanDuel. With a game total of 51 points, stacking Brees and Cooks has a high floor with tremendous upside.